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CANNABIS: modes of delivery Dr. Roberta DeLuca JD PhD

By Dr. Roberta DeLuca JD PhD

Cannabis acts on the body via the Endocannabinoid system (ECS). The ECS is a body system, just like the digestive system, the respiratory system, circulatory system, etc. The ECS is the most recently discovered body system ECS is present in all of our body tissues and organs.

Since the ECS exists in all of the tissues and organs of the body, the ECS also regulates the function of the immune, cardiovascular, musculoskeletal, and nervous systems, Thus , there is a profound influence on every aspect of our health.

In addition, the ECS includes CB1 and CB2 receptors. These receptors function with Cannabinoids to form a “lock and key”. This lock and key function works to balance certain body deficiencies, also known as “Endocannabinoid deficiencies” . The “lock and key” function, brings the body back into homeostasis (balance).

Since CBD users are able to use liberal doses without side effects, CBD can, in many ways, mimic the benefits organs of the body and reside in the CB1 and CB2 receptors.

CBD can in many ways regulate the function of the immune, musculoskeletal, and nervous systems, and thus has a profound influence on every aspect of our health.

Tetrahydrocannabinol users have been shown to induce transient symptoms of psychosis among healthy and is thought to be a risk factor in developing psychosis. Conversely, CBD is theorized to have antipsychotic and anxiolytic properties.5

Regarding medical utility, there is moderate-quality evidence that THC may help chronic neuropathic or cancer pain and that THC and CBD may benefit patients who have spasticity owing to multiple sclerosis.6 In addition, low-quality evidence suggests that cannabinoids may help nausea and vomiting secondary to chemotherapy.6 Currently, CBD is being studied for its possible antiseizure and anti-inflammatory properties.7

While CBD can, in many ways, mimic THC action, Cannabidiol is non-addictive, non-toxic and has a positive safety profile. Like THC, CBD affects a wide variety of medicinal and therapeutic benefits.

While both CBD and THC act upon the ECS, CBD is more gentle and forgiving (and it is “nonpsychoactive!”). Conversely, THC is “psychoactive” and users experience a narrow therapeutic window meaning too low or too high of a dose can either fail to provide a benefit or may cause adverse effects. Therefore, most CBD users can use CBD without side effects.

The health benefits of CBD may include improvements in:

  • Inflammation
  • Mood and Anxiety
  • Improve sleep
  • Resilience to stress
  • Congnition
  • Neurologic healing
  • Pain signaling
  • Gut function
  • Tissue recovery after exercise or injury
  • Current and future animal and human health benefits or medicinal purposes.

The 7 Methods of Cannabis Delivery and Routes Used-


Sublingual Tinctures- via Dropper

This mode of delivery is typically deliveredsublingually under the tongue via a small dropper. The reason for this is the tongue and the cheek “(buccal) are excellent methods of quick delivery.Thisis method avoids having to pass through the digestive system. 

This is evidenced by the observation that whole cannabis extract causes fewer psychological side effects (e.g., symptoms of dysphoria, depersonalization, anxiety, panic attacks, and paranoia) than comparable doses of synthetic, pure THC (Grinspoon & Bakalar, 1997).This observed difference in side effects may also be attributed to differences in route of administrationa small dropper which delivers a personal measure of cannabis drops. As in the “old days” of“apothecary” where a chemist was the an “alchemist”, and the product was called a “tincture”). It is either placed under the tongue or in the side of the mouth (Buccal) , where the salivary glands reside.

The Sublingual method of delivery is my favorite. This product absorbs under the tongue rather than subjecting it to the digestive tract. It preserves more of the CBD and you’ll feel results faster. Sublingual products take effect faster than edible products. Choose this route if you’re looking for quick results.Very discreet, it allows for precise dosing down to a single drop.

Smoking – This was the most typical method of ingestion in past history. Now that more is known about the dangers people have , I.e.,cardiopulmonary conditions, that preclude them from where the salivary glands reside., it’s not always the most discrete or other ingestion methods have arisen. A convenient way to consume cannabis, and especially amid the coronavirus pandemic, many people might want to not take any risks with their lungs. 

Vaping- Vaping heats up cannabis to a level that releases cannabinoids and other compounds into the air, producing a vapor which is then inhaled. There is no smoke, it’s more discreet and easier on the lungs, and can accommodate a wide range of products including oils, resin, and concentrates

Topicals – The skin is an excellent mode of delivery. Applied directly to the skin, cannabis balms, gels, salves and lotions can be used to treat pain, muscle aches and more. They do have a much lower bioavailability than other methods of ingestion, and should not produce a psychotropic 


Edibles are gaining popularity with the public. It should be noted that edibles have a longer onset of action. The infamous “pot brownie” of the 60s and 70s is now joined by infused gummies, lemonades, coffee, cookies and candy. Edibles are a potent and powerful way to consume cannabis without smoking and edible consumption, (even in the most non-weed friendly environments), is discrete so no one is the wiser.


CBD and other forms of cannabis pills, capsules, and tablets allow for precise dosing, are without the calories or cooking of edibles. A traditional way of taking medication is often an attractive option for those who view CBD, medicinal marijuana or CBD with skepticism and abhor the idea of smoking. Talk to your doctor about what might be right for you. 

Note: If you take warfarin, or other long-term drugs, please share this with your doctor. There are very few drugs n this category, but is possible there could be some adverse effects.

Categories:BlogECSModes Of Delivery Radicalreliefandwellness@gmail.comDr. Roberta (Bo) Forrest))  DeLuca, FACHEhttps://www.cbdbiocare.com/collections/all? You

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